演讲题目
The mobile oral microbiome — oral bacteria in extra-oral infections and inflammation

Yiping W. Han

美国微生物科学院院士 哥伦比亚大学教授

Research interest
My research has been consistently funded by the NIH and involves the role of microbes in human health and disease. My research interests include host-pathogen interactions, human microbiome and oral-systemic connections. The human microbiome is a vast population of microbes that play an essential role in health and disease. Work in our laboratory is focused on the following aspects: (i) investigating the role of oral bacteria in extra-oral infection and inflammation; (ii) investigating the mechanisms of Fusobacterium nucleatum pathogenesis in pregnancy complications and gastrointestinal cancers; and (iii) developing genetic tools for mutant construction in bacteria.

Selected Publications
Rubinstein, M.R., Baik, J.E., Lagana, S.M., Han, R.P., Raab, W.J., Sahoo, D., Dalerba, P., Wang, T.C. and Han, Y.W. (2019) Fusobacterium nucleatum promotes colorectal cancer through induction of novel Wnt/b-catenin modulator Annexin A1 in proliferating cancerous cells. EMBO Reports doi.org/10.15252/embo.201847638.1. PMID:30833345

Garcia-So, J., Zhang, X., Yang, X., Rubinstein, M.R., Mao, D.Y., Kitajewski, J, Liu, K. and Han, Y.W. (2019) Omega-3 fatty acids suppress Fusobacterium nucleatum-induced placental inflammation originating from maternal endothelial cells. JCI Insight 4: e125436. doi.org/10.1172/jci.insight.125436. PMID: 30728337

Vander Haar, E.L., So, J., Gyamfi-Bannerman, C. and Han, Y.W. (2018) Fusobacterium nucleatum and adverse pregnancy outcomes: Epidemiological and mechanistic evidence. Anaerobe 50: 55-59. PMID: 29409815